Rita levi montalcini biography of alberta
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In the trenches with Viktor Hamburger and Rita Levi-Montalcini (1965–1974
Int. J. Devl Neuroscience 19 (2001) 143– 149 www.elsevier.nl/locate/ijdevneu In the trenches with Viktor Hamburger and Rita Levi-Montalcini (1965 – 1974) One student’s perspective Robert R. Provine * Department of Psychology, Uni6ersity of Maryland Baltimore County, Baltimore, MD 21250, USA 1. Introduction Fig. 1. Viktor Hamburger and Rita Levi-Montalcini together in 1986 (photograph provided by R. Oppenheim). In September of 1965, I came to Washington University (St. Louis) as a psychology graduate student seeking training in what later became known as * Corresponding author. Tel.: + 1-410-4552419. E-mail address: provine@umbc.edu (R.R. Provine). neuroscience. The student neuroscientist of that era had to be an entrepreneur, fashioning a curriculum from a hodge-podge of courses in the Departments of Psychology, Biology, Engineering, and offerings on the medical school campus. I searched widely, looking for t
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The Nobel Prize in Chemistry 2015
Tomas Lindahl, Paul Modrich and Aziz Sancar for mechanistic studies of DNA repair
The Nobel Prize in Chemistry 2009
Venkatraman Ramakrishnan, Thomas A. Steitz and Ada E. Yonath for studies of the structure and function of the ribosome
The Nobel Prize in Chemistry 2003
for discoveries concerning channels in fängelse membranes
Peter Agre for the discovery of water channels
Roderick MacKinnon for structural and mechanistic studies of ion channels
The Nobel Prize in Chemistry 1993
for contributions to the developments of methods within DNA-based chemistry
Kary B. Mullis for his invention of the polymerase chain reaction (PCR) method
Michael Smith for his fundamental contributions to the establishment of oligonucleotide-based, site-directed mutagenesis and its development for protein studies
The Nobel Prize in Physiology or Medicine 1986
Stanley Cohen and Rita Levi-Montalcini “for their discoveries of growth fa
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Abstract
Nerve growth factor (NGF) is a protein whose importance to research and its elucidation of fundamental mechanisms in cell and neurobiology far outstrips its basic physiological roles. It was the first of a broad class of cell regulators, largely acting through autocrine and paracrine interactions which will be described herein. It was of similar significance in establishing the identity and unique roles of neurotrophic factors in the development and maintenance of the peripheral and central nervous systems. Finally, it contributed to many advances in the elaboration of cell surface receptor mechanisms and intracellular cell signaling. As such, it can be considered to be a “molecular Rosetta Stone”. In this brief review, the highlights of these various studies are summarized, particularly as illustrated by their coverage in the 13 NGF international meetings that have been held since 1986.
Keywords: growth factors, neurotrophins, cell signaling, receptors, central nervous