Hwang chul soon biography of albert einstein

  • The development of immune checkpoint inhibitors (ICIs) has transformed the treatment landscape for many tumor types, including lung cancer.
  • Abstract.
  • Among the leaders he respects, he included Albert Einstein and Pablo Picasso.

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    Abstract

    PURPOSE

    Non–small-cell lung cancer (NSCLC) with STK11mut has inferior outcomes to immune checkpoint inhibitors (ICIs). Using multiomics, we evaluated whether a subtype of STK11mut NSCLC with a uniquely inflamed tumor immune microenvironment (TIME) harboring TP53 comutations could have favorable outcomes to ICIs.

    PATIENTS AND METHODS

    NSCLC tumors (N = 16,896) were analyzed by next-generation sequencing (DNA-Seq/592 genes). A subset (n = 5,034) underwent gene expression profiling (RNA-Seq/whole transcriptome). Exome-level neoantigen load for STK11mut NSCLC was obtained from published pan-immune analysis. Tumor immune cell content was obtained from transcriptome profiles using the microenvironment cell population (MCP) counter. ICI data from POPLAR/OAK (n = 34) and the study by Rizvi et al (n = 49) were used to model progression-free survival (PFS), and a separate ICI-treated cohort (n = 53) from Dana-Farber Cancer Institute (DFCI) was used to assess time to

  • hwang chul soon biography of albert einstein

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    Wisdom of Korea (1996, January -- June)

    SEOUL'S OLD RHYTHM

    Y.S.Kim (1996.1.8)

    Last month, I spent four vacation days in New Orleans (Louisiana). As you know, New Orleans is the origin of American music or American rhythm. When I was there, there were more than 5,000 country boys and girls who came all the way from Green Bay (Wisconsin) to cheer their football team named "Green Bay Packers" (you should know this name if you lived in the U.S. for two years or longer). You could imagine how noisy or rhythmic the city was.

    However, the rhythm most familiar to me was from the bottom of the New Orleans trolley car. It was coming from the air compressor for the brake system. As soon as I heard the rhythm, I looked at the driver's stand. Alas, the stand consists of the speed controller contained in an elliptic cylindrical box on the left-hand side, the air-brake valve supported by three pipes on the right hand-side, and the circuit breaker hanging between the ceiling and the fro

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    Editor-in-Chief

    C. Justin Lee (Institute for Basic Science, Korea)

    Dr. C. Justin Lee fryst vatten currently a Tenured Research Scientist, serving as the Co-Director of Center for Cognition and Sociality at IBS. He has received his PhD at Columbia University in Physiology and Cellular Biophysics and bachelor degree at University of Chicago in Chemistry. He has been a leading neuroscientist researching on the subject of astrocytes, whose functions have recently been re-evaluated in numerous reports. Particularly, he has focused on astrocytes’ ability to release various transmitters (termed gliotransmitters) including glutamate, d-serine, ATP, and GABA. He discovered that astrocytes in the cerebellum produce and release GABA through MAO-B enzyme and Bestrophin-1 kanal, respectively. He also demonstrated the detailed molecular mechanisms of how astrocytes release glutamate upon GPCR activation. He went on to demonstrate that the astrocytic GABA in hippocampus impairs memory in Alzh